

🐕🦺 Elevate your pet’s skin health game—because they deserve the best!
Douxo S3 Pyo Shampoo is a premium antiseptic and hydrating formula containing 3% Chlorhexidine and 0.5% Ophytrium, designed to combat bacterial and yeast skin infections in dogs and cats. Recommended by U.S. veterinarians, it soothes irritated skin, supports the skin’s natural barrier, and delivers visible improvements within a week. Free from harsh chemicals, this 6.7 fl. oz. shampoo offers a gentle yet effective solution for maintaining healthy, soft, and shiny coats.





| Brand | Douxo |
| Customer Reviews | 4.7 out of 5 stars 6,864 Reviews |
| Item Form | Liquid |
| Liquid Volume | 6.7 Fluid Ounces |
| Material Type Free | Paraben Free,Sulfate Free |
| Product Benefits | Soothing,Moisturizing,Detangle |
| Recommended Uses For Product | For Bacterial or Yeast Skin Infections For Dogs and Cats |
T**S
Amazing Stuff - fixed my dog's skin issues!
My dog had maybe a yeast infection, skin allergies... idk. He had scabs and dandruff all over his back and belly, and lots of discoloration on his belly which came out of nowhere, He was constantly itching and I felt so bad for him ): I decided to look into it and found people with similar issues. So, with recommendations, I found this shampoo, and also switched his dog food to a better one. With the switch of his dog food, I can't say that one or the other fixed his skin, or both was the solution, but either way, his skin and coat has made a DRASTIC change in just one month. I have been washing him every 3-4 days with this shampoo for a month now, scrubbing him very well and leaving it to sit on him for 5-10 mins. He hates baths but it's what we have to do! This stuff smells great, it suds up and has a nice lather, rinses well, and leaves his coat feeling soft and clean! I can't complain at all. Yes it is pricey as heck, but if it works how can I complain. when I was researching on the internet for my dog's specific issues, I saw people with similar issues say their dog had a yeast infection, and when they took their dog to the vet, this is what their vet recommended! This is what made me take the jump on the purchase and I was not disappointed.
H**R
5 Stars - HIGHLY Recommend! Works Amazing for Allergies!
Hands down the best dog shampoo I've ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he's allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I'm averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I'll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent! The smell is really great as well, it's a lighter scent, I don't smell any chemicals or any of the normal medicated smell at all & it's light enough you can smell it on your pup if you're up close, but otherwise it's not noticeable. The formula is decently thick, it's not runny at all, but it suds up so great as well - another huge thing most medicated shampoos don't do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it's so easy to suds up, that you don't need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that's about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don't have to worry about it leaking, we transport it every weekend to our MIL's house, and I just throw it in the bag, never leaked before, you don't have to worry about it. I can't recommend this shampoo enough or stress how well its been working for our 4 dogs!
L**Y
Good product that works!
Finally, relief for our chi’s yeasty skin! Cleared up her itchy red skin immediately and it hasn’t come back. Our girl smells fresh and is comfortable and cozy after her bath again. She seems to stay clean longer too, which means I don’t have to bathe her as frequently.
S**A
Excellent result
I liked it very much, the result on my dog's skin, it felt much less itchy, after using it.
S**M
Worth EVERY Penny
This shampoo has been an absolute game-changer for my dog. She’s 13 years old now and has struggled with itching her entire life. We’ve tried just about everything over the years—multiple prescriptions, countless vet-recommended products, and so many over-the-counter solutions. Nothing ever gave her real relief until we started using this shampoo along with the mousse. The difference has been incredible. She used to spend her days constantly scratching and licking, and nights were often the worst—waking up itching, sometimes even crying out in discomfort. It was heartbreaking to watch. Since switching to this product she’s finally comfortable. She sleeps peacefully through the night now, complete with the sweetest little snores, and during the day she’s relaxed instead of restless. It’s been amazing to see her quality of life improve so dramatically. I’ve been using this consistently for months and I’m a repeat purchaser—I’ll never be without it. It not only calms her skin but also keeps her coat soft, clean, and so fresh smelling. I did find that buying directly from the company offers a better price, but regardless, this shampoo (and mousse) are worth every penny. If you have a dog struggling with chronic itching or irritated skin, I can’t recommend this product enough. It has truly been the only thing that has worked for us after years of searching, and it’s given my dog the comfort she deserves.
B**R
Works well!!
This is a great shampoo for my maltipoo. It smells nice and decreases his itchiness.
M**S
Great for treating Domadex in dogs.
Purchased to treat my Boston Terriers Domadex skin issues. Noticed an improvement within a week of bathing them every other day. I use this regularly now to help control skin irritation and itching. Great shampoo.
A**R
Amazing product for bacteria or fungal infections and maintenance
This stuff works great. My dog was always smelly, itching and loosing patches of hair. The vets had recommended I bathe him with regular dog shampoo two to 3 times a week. I had been giving him an expensive anti itch pill which worked for the itch, we kept treating him with antibiotics which made it go away for a bit. But once he stopped the meds, the smell and hair loss continued. Then I finally saw a vet who recommended this shampoo and the mousse with the same name. At first I used the shampoo every other day for about a week. Then went down to bathing once a week, using the mousse every other day. The hair immediately started coming back. He no longer smells like he use to and all his blankets that still smelled after I washed them stopped smelling. He must have had a fungus and bacteria. That was a couple years ago. He no longer needs the anti itch pill either. Now I just use the shampoo every few weeks with the mousse a couple times a week. He did have one or 2 patches of hair loss a couple times since then when I was not following up with the mousse. But concentrating the mousse on those patches and another shampoo, corrected it right away. Do make sure to leave it on the whole 10 min recommended before rinsing if they have a current infection. I tried leaving it on only 5 min one time and had to bathe him again the next day since the hair continued to fall out.
Trustpilot
1 week ago
2 weeks ago