Vetoquinol Zylkene Calming Support Supplement for Small Dogs and Cats, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs and Cats, 75mg

I got a small box of this first out of concerns my very picky cat wouldn’t like the powder mixed in with his food. He barely likes snacks. Well- he loved it- so I’ll be buying larger quantities in the future. I think it’s helping with his anxiety as well which was the purpose of buying it. Only downside is the price.

It took a week or so but my 17 yea old cat with dementia and other illnesses calmed down. He had been up all night, yowling and walking up and down our bed multiple times. Now he seems much more comfortable and able to relax at night. It’s not 100% but way better than before. I have to put it in a pill popper to give it to him but you could open the capsule and sprinkle on food.

My experience comes from a cat shelter and, in recent years, working as a professional cat behavior consultant. It's hard to know with supplements if they really are effective, especially when they are used in conjunction with other behavior modification strategies. I can say that I used them with my cats for about a month as we were transitioning into our new home, and I thought they were helpful. I like that they have fewer potential side effects than prescription medication. Most cats don't mind the taste. For cats with more discerning taste, you can give the gel caps whole, on a lick mat in a pile of mixed-texture treats. The only drawback, from my perspective, is these supplements are pricey, which makes them less feasible for long-term use.

I have a 4-year-old Maine Coon with a sensory processing disorder. My big boy, Barnum, has trouble processing textures and noises. I have the only Maine Coon in America who HATES to be brushed no matter the brush or comb used. (We have 12.) Everyday noises — the doorbell, microwave alarm, TV volume — completely unhinge him and send him running for his life. Prozac helped to some degree, but it also flattened him emotionally and didn’t fully address the sensory overload. Since adding Zylkene alongside an reduced Prozac dose, the change has been remarkable. Barnum is calmer (no longer flinching when the duct work in the attic pops or the ice maker drops ice), more social, and genuinely enjoying life again. He seeks affection, engages in play, and even participates in brush sessions willingly (with freeze dried chicken incentives!). The difference is subtle but profound — his nervous system feels soothed, not sedated. I give him 1 capsule every morning. 2 made him sleep all day. Zylkene has balanced his sensory overload and allowed his personality and spirit to come back. He’s alert but regulated, playful but not anxious, and much more comfortable navigating the household and daily life. Any owner of a cat with anxiety or sensory issue should try Zylkene. Worth every penny!

It works but I wanted something where my cat could just enjoy chilling out with family, I know cats sleep a lot anyway but this really knocks him out where I don’t get enough time with him. I hope that eventually he will relax in his new home and I can enjoy quality time with him.