I have MTHFR mutations, specifically the compound mutation, C677T and A1298C. Insomnia is linked to the A1298C, and I do have insomnia. I have tried a number of different products but had not been able to find anything that really worked well. This product was recommended to me by a naturopath as a sleep aid, 1-2 capsules at bedtime, and if I wake up, another capsule. It works. I still don't quite have the dosing down, and will continue to experiment. It seems gentle. I do not wake up groggy, but do wake up at my normal time. This product is doing quadruple duty for me. I am a breast cancer survivor that remains concerned about recurrance. If you look at Wikepedia with regard to honokiol, the active ingredient in this product, you will find that it has what the naturopth described as "profound anti-cancer properties." It is clinically proven to have anti-tumorigenic effects. So it will help prevent recurrance of cancer. The C677T is also associated with clotting problems and resulting heart attacks, strokes and other circulatory problems. Honokiol is also anti-thromobotic in effect. Lastly, I also have GAD mutations, which cause imbalances in the glutamine-GABA balance. I take phenibut and GABA to help balance against glutamine. I am therefore very sensitive to glutamin in the diet, and avoid it by avoiding avoid foods that are naturally high in glutamine like gluten, dairy products and soy, along with avoiding any MSG or hydrolyzed anything. Because honokiol also acts on GABA receptors, it will help with the GAD issues. That may be why it is effective as a sleep aid. So it is providing me with restful sleep, anti-cancer properties, anti-thrombotic properties, and assistance with GAD SNP's. It would be worth it alone to get a decent night's sleep. The rest of the effects are added bonuses.
