Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

Well it worked for me! I discovered Sam-e while doing some research on my own and decided to give it a try for my mild to moderate depression problems. It worked for me after about a week I started to notice a difference in my mood, I had more energy, and I was able to concentrate again. A few weeks after that i decided i didn't need it anymore and went off of it and a few days later I woke up feeling terrible with the same unpleasant feelings I had before I started taking it. Needless to say that night I went to the supermarket and bought some more. Now I just buy it from amazon because I know I need it and it offers the best value. I'll happily dish out forty bucks every two months if it helps me feel like this. I will note though that at first when I was switching brands I did have some gastrointestinal discomfort that was really unpleasant at first. It lasted off and on about three weeks, but then it stopped and I haven't had it since. I changed my diet to make sure I got about the same amount of fiber everyday to try and combat those problems and for me that seemed to work. I take one 400mg tablet every morning on an empty stomach and wait thirty minutes to an hour before eating anything. One time I ate something a few minutes after taking it and I did vomit so there's your warning, they actually do mean it when they say to wait to eat. Overall, I'm extremely happy with this product and if you don't believe these reviews look up some scholarly articles on it and the research speaks for itself, I believe they actually prescribe it for mild to moderate depression in countries like Germany. I've also read that st. john's wort works too for depression problems, but I've never tried it. A warning about st. john's though it can mess with the efficacy of birth control pills so I would be cautious about st. john's wort if you're taking birth control.

I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.

I’ve taken SAM-e for 2 decades now. I used to buy exclusively Nature Made and I like it but can’t seem to find it in the drugstores anymore where I used to get it BOGO frequently so I first tried this brand at Walmart and it was always pretty good. It’s one of only 3 that consumer lab recommended in their paid report. Anyone trying SAM-e its best to get it 2-2.5 years before the expiration date, in a blister pack, enteric coated, on an empty stomach and with folic acid, b6 & b12. This one checks all the boxes at a very good price. Not all SAM-e supplements have the amount they claim. I haven’t had issue with this brand. For mood you generally need about 1200-1600 mg a day to deal with any significant depression. The only reason it isn’t a drug (since it works better than most pharmaceuticals) is that it’s naturally occurring and not patentable. So it’s an expensive supplement instead. But I highly recommend it. And I only like this one or Nature Made or Natures Bounty (but I can’t find it anymore). Natures Trove is okay in a pinch but I think this might be the best of the less expensive brands.

Wife: "My husband takes these to not be so much of a jerk. When he takes it my jerk meter only detects 40% jerk levels. I recommend this for anyone dealing with a jerk." Husband: "These pills help me deal with my wife's constant nagging. When I take them, her nagging only bothers me 40% of the time. I recommend these to any husband having to deal with a naggy wife." In all seriousness, these help my husband maintain his mood. I wouldn't say he's an overly depressed person but he's always felt that his mood was slightly pessimistic and he's easily agitated by small things. Behavior modification can only do so much. He spoke to a psychiatrist about a correlation he noticed. When he took 5HTP his mood improved. The psychiatrist informed him that 5HTP was the precursor to serotonin. He took the 5HTP for awhile but it eventually became ineffective. He did some online research which led him to SAM-e 400. He decided to give it a try. He's been using it for 7 weeks and has experienced a significant increase in mood and his ability to manage stress. He still feels the emotions and agitation but the intensity is reduced enough that he can use behavior modification techniques more effectively. We, as a couple, fight less because he doesn't go too far in his extremes. I don't, personally, normally review supplements. I don't want anyone to get the impression that I'm telling you something like this will work for you or is even safe for you. I can only tell you that my husband had success with this and he had no adverse reactions. It's up to you to decide if this is safe for you and worth trying out. As always, if in doubt consult with a Dr. as I have no medical training. This is not a sponsored review, we've been paying full price for these for 7 weeks now. Note: My husband participated in the writing of this review. All information I've provided was directly from him and not 2nd hand.

Great product for liver support. Known as Heptral in Ukraine, and it has proven to be effective and reliable. Arrived well packaged and in good condition. Easy to use and feels like a quality product. Definitely a good option for maintaining liver health.

I bought this product after hearing that Dr. Oz recommended Sam-e for depression. Dr. Weil also recommends it but says you should look for the butanedisulfonate form. I tried emailing Doctor's Best to ask them about this, but the email was returned as undeliverable. However, I am no longer depressed so it seems to be working. I have suffered several major concussions which has been linked to major depression. I can get so depressed that I stop showering. I have been on and off SSRI antidepressants for years. They always stop working. I heard Dr Weil on NPR talking about his new book Spontaneous Happiness, and he said that the SSRIs have been linked to cancer and heart problems. The Mayo Clinic's website also says they can cause osteoporosis. Zoloft made me feel like I wanted to jump out of my skin. I take one Sam-e pill(400mg) a day on an empty stomach. This is very important if you want it to work. When I took 2 pills, it made me a little manic which was kind of fun, but I only really need 1 pill. The great thing about Sam-e is that if it is going to work for you, it will work within a week. My naturopath said that it doesn't work for everyone. Dr. Weil also recommended St. John's Wort, Rhodiola, and Ashwagandha for depression. Another important vitamin is vitamin D3. Most Americans are deficient in the sunshine vitamin. Dr. Weil recommends 2000i.u. a day. I've read that over 50% of all cancers could be prevented if people had adequate levels of vitamin D. Everyone should be tested for their levels. Optimal is between 50-70. Go to [...] to get more info of vitamin D. It also prevents depression. The best way to get it of course is from sun exposure, but for those who can't get sun, supplements are good. Dr. Mercola says that since sunscreens have gone into use, skin cancer has greatly increased. He thinks this is due to lack of vitamin D and the cancer causing ingredients in most sunscreens like any of the parabens.

I've been living with chronic back pain and several other chronic conditions for the past decade. My daughter has some of the same issues, and she recently found a Dr that determined what was wrong and prescribed a treatment program that made her much better. At her urging, I went to see her Dr, who put me through the Walsh Protocol screening. The blood test showed that I have the same problem my daughter has - a genetic defect called Undermethylation. As I understand it, the first indication of this condition is the histamine level in your blood. A normal person should score between 20 and 60, with 40 being average. My score was 79, which indicates a severe problem. My Dr is prescribing a rigorous program to address my issues, but she started me on SAM-e the day she got my test scores. I took my first dose right after waking up the next day, and within 10 minutes I could tell that I was feeling better. For the first time in my life, I am truly able to relax. I've been taking it 10 days now and feel much better in so many ways. A lifetime of tight muscles is not going to be corrected overnight, but for the first time in years I feel like I have hope of getting better. If you are considering trying this, I'd recommend you look up Undermethylation and see if you have the symptoms. I think it's extremely important for people to understand that SAM-e is probably not going to help you unless you have a high histamine score. If you have a score below 20, then you have the opposite condition - Overmethylation. If you have this, it's likely that SAM-e will make you worse. I believe this is the reason we see reviews all over the place, with some declaring it a great supplement and others saying it's worthless. It all depends on your body and what you need. In my case, there is no doubt that I inherited the disorder from my mother. She had many of the same symptoms. I told one of her brothers about SAM-e and he declared it a miracle after just 3 days of use. I hope that my review will prove helpful if you are considering trying SAM-e

Sam-e is only thing I found that helps my depression.

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This is the best SAM-e on the market. It’s effective at lifting mood, without any bad side effects. It doesn’t cause stomach upset, like some other brands.

this product is worth buying it helped my joint pain and added calmness as well

I ordered two boxes and when they arrived they both expired in four months' time. I'm not going to get through 120 tablets that quickly. Every time I've bought the exact same product from retail stores, the expiry date is always at least a year away. I don't think Doctor's Best should be trying to sneakily get rid of almost old stock like this. It's not respecting your customers. Happily, Amazon resolved it.