---
product_id: 86583438
title: "Differin Adapalene Gel 0.1% Acne Treatment"
brand: "differin"
price: "14105 som"
currency: KGS
in_stock: null
reviews_count: 4
category: "Differin"
url: https://www.desertcart.kg/products/86583438-differin-adapalene-gel-0-1-acne-treatment
store_origin: KG
region: Kyrgyzstan
---

# Gentle, water-based, non-comedogenic formula 180-day supply for long-term clear skin 0.1% Adapalene, Rx-strength retinoid power Differin Adapalene Gel 0.1% Acne Treatment

**Brand:** differin
**Price:** 14105 som
**Availability:** ❌ Out of Stock

## Summary

> ✨ Clear skin, no compromises — your 180-day glow-up starts now!

## Quick Answers

- **What is this?** Differin Adapalene Gel 0.1% Acne Treatment by differin
- **How much does it cost?** 14105 som with free shipping
- **Is it available?** Currently out of stock
- **Where can I buy it?** [www.desertcart.kg](https://www.desertcart.kg/products/86583438-differin-adapalene-gel-0-1-acne-treatment)

## Best For

- differin enthusiasts

## Why This Product

- Trusted differin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Gentle Yet Effective Formula:** Oil-free, fragrance-free, and dermatologist recommended for sensitive skin
- • **Long-Term Skin Health Support:** Reduces risk of scarring and hyperpigmentation with consistent use
- • **Clinically Proven Acne Reduction:** Up to 87% fewer breakouts in 12 weeks—real results you can trust
- • **Deep Pore Penetration in 5 Minutes:** Targets acne at the source to clear and prevent future breakouts
- • **Prescription-Strength Retinoid, No Rx Needed:** Harness the power of adapalene, the first OTC retinoid in 30+ years

## Overview

Differin Acne Treatment Gel delivers prescription-strength 0.1% adapalene retinoid in a gentle, water-based formula designed for sensitive, acne-prone skin. Clinically proven to reduce acne breakouts by up to 87% in 12 weeks, it works by normalizing skin cell turnover and targeting clogged pores and inflammation. This FDA-approved OTC retinoid penetrates deep within 5 minutes, preventing new acne while improving skin tone and texture. Ideal for daily use, Differin supports long-term skin health without harsh irritants, making it a dermatologist-recommended staple for clear, resilient skin.

## Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Review: It works if you're patient! - I have been using Differin for over a year now (around 14 months giver or take) and did not publish a review until now. If you want an in-depth review, read on. For the tl;dr version: it works, just stick with it. Btw, I was not paid for this nor was I sent this product (although they should be sending it, given how many tubes I've bought). I had the MOST TERRIBLE acne. No, I'm not talking about a small tiny excuse of a blemish that your friend with great skin complains about when she has her "bad skin" days. My face was RED and PAINFUL. My cheeks were COVERED all the time, and I had no area on my face where acne wouldn't pop up. Nose, brows, chin, jaw, underneath the jaw, you name it. I had tried Curology and while my skin got amazing for the first 6 months, my acne returned with a VENGEANCE. I had tried so many things, clay masks, benzoyl peroxide, salicylic acid, other AHAs and BHAs, sulfur, rosehip oil, and even supplements like zinc and milk thistle, you name it. Nothing worked at all. I was so so embarrassed of my skin, but I couldn't wear makeup either since makeup made my acne SO MUCH worse. I heard about Differin and I figured "well, might as well give this a try cause it can't get any worse". Boy, I was wrong. It did get worse. Much worse. Suddenly I had SO much more acne and I felt like crap. I couldn't believe my skin could get worse, but it did. Differin was the only thing I was using so I knew this was it. I was depressed but I stuck with it, cause I wanted to test it for at least 4 months. I thought I might as well test the claim, since my skin is so bad already. The first month was really really bad. It brought all underlying acne to the surface i.e. the purge phase. It did the purging for 3-4 months, but the first month was THE WORST. Not gonna lie to you, that first month will probably be the worst skin you've had in your life. Your skin will become SO SENSITIVE! Anticipate that! My skin has never been sensitive to products but while using this, my regular moisturizers and masks would sting like crazy (get stuff with no fragrance/alcohol or acids!). It didn't affect my skin in any other way, it just stung a lot. Oh, and I used to get my upper lip and brows waxed. Not with this you can't, the wax will tear off your skin since it gets much more sensitive. I learned the hard way. ONLY do threading! However, after I waited out the terrible, terrible first month, I slowly began to see improvements. Marginal, though. I had acne, but I probably had just a tad less. And it continued that way, it kept improving. Eventually, my skin was so much clearer than before! I still had acne, mind you, it's not a miracle drug, but it was few and far in between. There would be times when I had no active acne, which was HUGE for me!! My face usually looked like a connect the dots game. However, I did hit a plateau. This worked phenomenally at reducing my ugly acne all over my face to a few zits here and there, however, my issue was deeper than that. Eventually, I went to a doctor and got on spironolactone. Now, I am both on my Spiro and this. The combo of these two have made my skin so clear! I could have never imagined this day! I still need to use this, I have noticed my Spiro is not enough to keep zits at bay and if I skip a couple of nights putting on differin, new zits come up. I am so much happier now that I don't have zillions of gross zits on my face. I still get zits if I eat sugar or near my period but man, I am a long way from before! I have a few blemishes left over from before but I honestly don't care, my skin looks wayyy better. I can hide my blemishes with a sheer foundation of spot concealing if I want. So if you've read till the end, the lesson is: be PATIENT and be realistic! Your acne did not appear overnight and will not disappear overnight. If you stick with this, it WILL work. However, your mileage may vary. My acne was extremely bad, so after I hit my "acne plateau" I went to the doctor. If your acne is not as bad, it's likely differin is all you need for clear skin! If you're on the fence, confused, depressed, frustrated and/or can't afford a doctor, it's worth a shot! Just be patient and gentle with your skin!
Review: 100/100 Works When Used Correctly - Disclaimer: I am not a doctor. This is based on my personal experience. I’ve been using this product for two years, and I’ve noticed that many first-time users don’t fully understand what it’s meant to do. Yes, this product is supposed to dry your skin out. Dryness and flaking are normal and part of the process. It works by helping shed the acne-prone, irritated layer of skin and increasing cell turnover, which is why moisturizing is so important. Use only a pea-sized amount and apply it every other night. I strongly recommend wearing a MINERAL SUNSCREEN during the day. If you’re having an allergic reaction to another product, avoid adding sunscreen or new products and stay out of the sun until your skin calms down. Around the seven-day mark, I usually start seeing great improvement. This is one of the few retinoids that has truly worked for me. The dryness isn’t a bad reaction, it’s part of how the product works. When used correctly, the results are absolutely worth it. I give this product 100 out of 100. One of the best skincare products I’ve ever used.

## Features

- TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
- THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B07H5WQQL7 |
| Customer Reviews | 4.5 4.5 out of 5 stars (70,293) |
| Department  | Beauty & Personal Care |
| Item model number  | 0299.492045 |
| Manufacturer  | Galderma |
| Product Dimensions  | 6.38 x 7.88 x 7.44 inches; 2.08 ounces |
| UPC  | 302994920457 302990332995 |

## Product Details

- **Brand:** Differin
- **Item Form:** Gel
- **Product Benefits:** Anti-Acne
- **Scent:** Unscented
- **Skin Type:** Dry, Sensitive

## Images

![Differin Adapalene Gel 0.1% Acne Treatment - Image 1](https://m.media-amazon.com/images/I/71eUa4mSulL.jpg)

## Questions & Answers

**Q: What are retinoids, and why are they important in clearing acne?**
A: Topical retinoids play a crucial role in the treatment of acne. Retinoids have vitamin A activity and help regulate skin cell turnover to make sure your skin goes through the process effectively, creating a healthier environment for skin.

**Q: Is Differin Gel dermatologist developed and tested?**
A: Yes, Differin Gel is dermatologist developed and includes a dermatologist-recommended retinoid.

**Q: How long does Differin Gel take to work?**
A: Differin Gel starts working immediately, and results may be seen in as little as two weeks. However, It may take up to 3 months to see significant results, but with continued use, it’s been proven to work, so hang in there.

**Q: Are there any side effects?**
A: Common side effects include dryness, redness, irritation, and burning/stinging, peaking at 2-4 weeks before improving. Not everyone experiences these, and in studies, most had mild symptoms.

**Q: If I experience irritation, should I discontinue use? What can I do to minimize skin irritation?**
A: Irritation is a common reaction that usually fades after 4 weeks. Use Differin Gel once daily and a gentle, non-comedogenic moisturizer. If symptoms persist or irritation becomes severe, discontinue use and consult your physician before reapplying.

## Customer Reviews

### ⭐⭐⭐⭐⭐ It works if you're patient!
*by B***I on June 9, 2018*

I have been using Differin for over a year now (around 14 months giver or take) and did not publish a review until now. If you want an in-depth review, read on. For the tl;dr version: it works, just stick with it. Btw, I was not paid for this nor was I sent this product (although they should be sending it, given how many tubes I've bought). I had the MOST TERRIBLE acne. No, I'm not talking about a small tiny excuse of a blemish that your friend with great skin complains about when she has her "bad skin" days. My face was RED and PAINFUL. My cheeks were COVERED all the time, and I had no area on my face where acne wouldn't pop up. Nose, brows, chin, jaw, underneath the jaw, you name it. I had tried Curology and while my skin got amazing for the first 6 months, my acne returned with a VENGEANCE. I had tried so many things, clay masks, benzoyl peroxide, salicylic acid, other AHAs and BHAs, sulfur, rosehip oil, and even supplements like zinc and milk thistle, you name it. Nothing worked at all. I was so so embarrassed of my skin, but I couldn't wear makeup either since makeup made my acne SO MUCH worse. I heard about Differin and I figured "well, might as well give this a try cause it can't get any worse". Boy, I was wrong. It did get worse. Much worse. Suddenly I had SO much more acne and I felt like crap. I couldn't believe my skin could get worse, but it did. Differin was the only thing I was using so I knew this was it. I was depressed but I stuck with it, cause I wanted to test it for at least 4 months. I thought I might as well test the claim, since my skin is so bad already. The first month was really really bad. It brought all underlying acne to the surface i.e. the purge phase. It did the purging for 3-4 months, but the first month was THE WORST. Not gonna lie to you, that first month will probably be the worst skin you've had in your life. Your skin will become SO SENSITIVE! Anticipate that! My skin has never been sensitive to products but while using this, my regular moisturizers and masks would sting like crazy (get stuff with no fragrance/alcohol or acids!). It didn't affect my skin in any other way, it just stung a lot. Oh, and I used to get my upper lip and brows waxed. Not with this you can't, the wax will tear off your skin since it gets much more sensitive. I learned the hard way. ONLY do threading! However, after I waited out the terrible, terrible first month, I slowly began to see improvements. Marginal, though. I had acne, but I probably had just a tad less. And it continued that way, it kept improving. Eventually, my skin was so much clearer than before! I still had acne, mind you, it's not a miracle drug, but it was few and far in between. There would be times when I had no active acne, which was HUGE for me!! My face usually looked like a connect the dots game. However, I did hit a plateau. This worked phenomenally at reducing my ugly acne all over my face to a few zits here and there, however, my issue was deeper than that. Eventually, I went to a doctor and got on spironolactone. Now, I am both on my Spiro and this. The combo of these two have made my skin so clear! I could have never imagined this day! I still need to use this, I have noticed my Spiro is not enough to keep zits at bay and if I skip a couple of nights putting on differin, new zits come up. I am so much happier now that I don't have zillions of gross zits on my face. I still get zits if I eat sugar or near my period but man, I am a long way from before! I have a few blemishes left over from before but I honestly don't care, my skin looks wayyy better. I can hide my blemishes with a sheer foundation of spot concealing if I want. So if you've read till the end, the lesson is: be PATIENT and be realistic! Your acne did not appear overnight and will not disappear overnight. If you stick with this, it WILL work. However, your mileage may vary. My acne was extremely bad, so after I hit my "acne plateau" I went to the doctor. If your acne is not as bad, it's likely differin is all you need for clear skin! If you're on the fence, confused, depressed, frustrated and/or can't afford a doctor, it's worth a shot! Just be patient and gentle with your skin!

### ⭐⭐⭐⭐⭐ 100/100 Works When Used Correctly
*by M***A on January 14, 2026*

Disclaimer: I am not a doctor. This is based on my personal experience. I’ve been using this product for two years, and I’ve noticed that many first-time users don’t fully understand what it’s meant to do. Yes, this product is supposed to dry your skin out. Dryness and flaking are normal and part of the process. It works by helping shed the acne-prone, irritated layer of skin and increasing cell turnover, which is why moisturizing is so important. Use only a pea-sized amount and apply it every other night. I strongly recommend wearing a MINERAL SUNSCREEN during the day. If you’re having an allergic reaction to another product, avoid adding sunscreen or new products and stay out of the sun until your skin calms down. Around the seven-day mark, I usually start seeing great improvement. This is one of the few retinoids that has truly worked for me. The dryness isn’t a bad reaction, it’s part of how the product works. When used correctly, the results are absolutely worth it. I give this product 100 out of 100. One of the best skincare products I’ve ever used.

### ⭐⭐⭐⭐⭐ Worth the purchase
*by A***A on December 8, 2025*

Overall I was surprised by the results and effectiveness of this product. Im writing this review a month after using this adapalene gel because I wasn’t sure how well it was going to work. A month ago I had been dealing with a bad breakout on my forehead, temples, and jawline. I had been using either salicylic acid treatment or benzoyl peroxide on my face. Neither of those products made my situation any better. This product has been on my saved for later list for a while so I was curious to try something different for once. The first week and a half I didn’t see much change. But by week two and three, my goodness my acne nearly vanished. And I’m not exaggerating. It’s been a month now of wearing this every night after my nighttime routine. My face is smooth, acne and bumps are almost completely gone. Even the dark scars from some acne have gone away. It works really well and the 30-day supply really does last for 30-days. The skin around my eyes do dry out with this product, so I’ve been applying Vaseline to help with the excessive dryness. Otherwise this product really helped in just one month use. I spot treated acne on my chest and shoulders every now and then and this works for body acne too. I’m very impressed with the results. 95% of my acne is gone, with some trouble areas like my temples. But it’s helped a lot. I wish I took comparison photos to show the difference.

## Frequently Bought Together

- Differin Acne Treatment Gel, 180 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Tube, Pack of 2 (Packaging May Vary)
- PanOxyl Acne Foaming Wash Benzoyl Peroxide 10% Maximum Strength Antimicrobial, 5.5 Oz
- Differin Acne Face Wash with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Foaming Cleanser, Fast Acting Acne Treatment for Face and Body, 5 oz.

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*Product available on Desertcart Kyrgyzstan*
*Store origin: KG*
*Last updated: 2026-01-24*