---
product_id: 56267268
title: "Expression and Mutational study of recombinant mouse IRF-2: Wild versus Mutant recombinant mouse IRF-2: expression and DNA binding activity study"
brand: "krishna prakash"
price: "24693 som"
currency: KGS
in_stock: true
category: "Paperback"
url: https://www.desertcart.kg/products/56267268-expression-and-mutational-study-of-recombinant-mouse-irf-2-wild
store_origin: KG
region: Kyrgyzstan
---

# Expression and Mutational study of recombinant mouse IRF-2: Wild versus Mutant recombinant mouse IRF-2: expression and DNA binding activity study

**Brand:** krishna prakash
**Price:** 24693 som
**Availability:** ✅ In Stock

## Quick Answers

- **What is this?** Expression and Mutational study of recombinant mouse IRF-2: Wild versus Mutant recombinant mouse IRF-2: expression and DNA binding activity study by krishna prakash
- **How much does it cost?** 24693 som with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.kg](https://www.desertcart.kg/products/56267268-expression-and-mutational-study-of-recombinant-mouse-irf-2-wild)

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## Description

IRF-2 is a mammalian transcription factor for interferon and interferon inducible genes of having oncogenic activity under certain circumstances.We compared the amino acid sequences of mouse IRF-2 (349 amino acid) with human IRF-2 and found a C-terminal tetra-peptide  (314PAPV317) of mouse IRF-2 to be different from (314SSSM317) human IRF-2 (349 amino acid). The murine IRF-2 sequence (PAPV) at 314-317 was replaced by SSSM, the corresponding region of the human IRF-2, by site-directed cassette mutagenesis. Both the wild type and mutant IRF-2 were prepared as GST-fusion proteins expressed in E. coli XL-1 blue cells, which exhibited similar expression patterns and immunoreactivity but different DNA-binding activities with (GAAAGT)4 oligonucleotide. The mutant IRF-2 showed higher complexes than the wild type IRF-2. Also, the amount of the complexes was higher in the mutants. Although the mouse and human IRF-2 are molecularly homologous and physiological similar, replacement of the four amino acid in mouse IRF-2 by the corresponding region from human IRF-2 can influence DNA binding activity of IRF-2. This provides new information on the function of C-terminus of IRF-2.

## Features

- Expression and Mutational Study of Recombinant Mouse Irf 2

## Images

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*Product available on Desertcart Kyrgyzstan*
*Store origin: KG*
*Last updated: 2026-02-24*