---
product_id: 257288700
title: "THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules"
brand: "thorne"
price: "19569 som"
currency: KGS
in_stock: true
reviews_count: 5
category: "Thorne"
url: https://www.desertcart.kg/products/257288700-thorne-methyl-guard-methylation-support-supplement-with-folate-and-vitamin
store_origin: KG
region: Kyrgyzstan
---

# Pure, allergen-free formula 180 capsules for 6-month supply Supports healthy methylation THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules

**Brand:** thorne
**Price:** 19569 som
**Availability:** ✅ In Stock

## Summary

> 🧠 Elevate your vitality with every capsule—because your health deserves the best!

## Quick Answers

- **What is this?** THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules by thorne
- **How much does it cost?** 19569 som with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.kg](https://www.desertcart.kg/products/257288700-thorne-methyl-guard-methylation-support-supplement-with-folate-and-vitamin)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Long-Lasting Supply:** One capsule daily delivers a 6-month supply—effortless wellness continuity
- • **Clean & Pure Formula:** Free from gluten, soy, dairy, shellfish, nuts, and major allergens for peace of mind
- • **Comprehensive Wellness Boost:** Supports heart, brain, nerve, blood vessel, and bone health in one capsule
- • **Precision Methylation Support:** Optimized with active 5-MTHF & methylcobalamin for superior absorption
- • **Homocysteine Metabolism Enhancer:** Promotes healthy homocysteine levels to support cardiovascular health

## Overview

THORNE Methyl-Guard is a premium methylation support supplement featuring bioactive folate (5-MTHF) and methylcobalamin (B12) designed to enhance methylation processes, promote healthy homocysteine metabolism, and support cardiovascular, neurological, and bone health. With 180 allergen-free capsules, it offers a convenient 6-month supply tailored for adults seeking clean, effective supplementation.

## Description

THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules : desertcart.ae: Automotive

Review: Excellent product for MTHFR genetic disorder
Review: I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

## Features

- Methylation: Support for healthy methylation*
- Multiple Functions: Support for heart, blood vessel, brain, nerve, and bone health*
- Homocysteine: Promotes homocysteine metabolism*
- Active Bs: Contains the active, methylated forms of folate and vitamin B12 (5-MTHF and methylcobalamin)
- Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts) This product also contains no soy, dairy, shellfish, or fish

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0012FJVA2 |
| ASIN  | B0012FJVA2 |
| Age Range Description | Adult |
| Allergen Information | Shellfish Free |
| Best Sellers Rank | #2,374 in Health ( See Top 100 in Health ) #64 in Multiple Vitamin-Mineral Combination Supplements |
| Brand | THORNE |
| Customer Reviews | 4.7 4.7 out of 5 stars (2,625) |
| Customer reviews | 4.7 4.7 out of 5 stars (2,625) |
| Date First Available | 9 August 2012 |
| Format | Capsule |
| Is Discontinued By Manufacturer  | No |
| Manufacturer  | Thorne Research |
| Manufacturer reference  | SF787-R |
| Product Dimensions  | 7.34 x 7.34 x 13.26 cm; 0.18 g |
| Units | 180 Count |
| Weight | 0.45 Pounds |

## Product Details

- **Brand:** THORNE
- **Diet type:** Gluten Free
- **Flavour:** Unflavored
- **Item form:** Capsule
- **Primary supplement type:** Vitamin B and Folate

## Images

![THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules - Image 1](https://m.media-amazon.com/images/I/61Cgh5TOkrL.jpg)

## Questions & Answers

**Q: Is there a scientific study that I can read that will back up these claims?**
A: Absolutely, there are studies!  There are enough that I need to ask you to be more precise in what you want to know.  Which ingredient are you interested in, for what population, and concerning what symptoms?  Your local library may be able to help you access research databases that will allow you to search to your heart's content.  State libraries may be used by any taxpayer, and some medical schools will allow community members a day pass.  Here is a little taste, notice how long this research has been going on: 1) Weisberg, I., Tran, P., Christensen, B., Sibani, S., & Rozen, R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular genetics and metabolism, 64(3), 169-172.2) Grandone, E., Margaglione, M., Colaizzo, D., Cappucci, G., Paladini, D., Martinelli, P., ... & Di Minno, G. (1997). Factor V Leiden, C> T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thrombosis and haemostasis, 77(6), 1052-1054.3) (The title for this one is unfortunate, it is a randomized, controlled clinical study which is the gold standard, and it found the reduced B vitamins to work to alleviate symptoms of major depression as well as homocystine levels. 4) Sontag, J.-M., Wasek, B., Taleski, G., Smith, J., Arning, E., Sontag, E., & Bottiglieri, T. (2014). Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in Aging Neuroscience, 6, 214. http://doi.org/10.3389/fnagi.2014.00214There is your taste!  There is also research showing lack of/poor sperm count in males with homozygous A1298C variant of MTHFR, higher risks of pre-eclampsia in pregnant women, etc., etc.,  At this point, I'm surprised that routine screening has not yet become a standard of care.  I hope that the variation of research articles here has helped you to understand why a more precise question is needed for a direct answer.  No single study will do it (and never does).  How about 2 decades of research?  :)

**Q: Ingredients?**
A: There seems to be some confusion about the difference between Methyl-Guard and Methyl-Guard PLUS, which costs twice as much as the regular Methyl-Guard listed on this page.Jana B.'s answers above seem to list the ingredients of the plus version, although the amounts appear to match that of the regular version. (?)This version does NOT have Riboflavin (B2) (Riboflavin 5'-Phosphate Sodium). In addition to B2, the plus version also claims to have more of all of the ingredients listed below.I have never purchased MG-Plus but I have a bottle of the regular Methyl-Guard in front of me.Here are the ingredients as listed:3 capsules contain:Vitamin B6 (as Pyridoxal 5'-Phosphate)   20.4 mg   1,020% DVFolate (as L-5 Methyltetrahydrofolate from L-5 Methyltetrahydrofolic Acid, Glucosamine Salt)   1.2 mg   300% DVVitamin B12 (as Methylcobalamin)   1.2 mg   20,000% DVBetaine Anhydrous (Trimethylglycine)   1.8 g   *DV not establishedOther Ingredients:Hypromellose (derived from cellulose) capsuleCalciumCitrateLaurate  (sic)Silicon DioxideSuggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner. (Personally, I only take 3 a day, not 6)

**Q: This states 180 capsules???**
A: Thorne Research - Methyl-Guard comes in a 180 capsule sized bottle.

**Q: What is the difference between the old label and the new label?**
A: Also some of the amounts are different. 
Old methyl guard:
Three Capsules Contain:
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg.
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE
Vitamin B12 (as Methylcobalamin) 1.2 mg.
Betaine Anhydrous (Trimethylglycine) 1.8 g.

New Methyl guard Plus:
Three Capsules Contain:
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE
Vitamin B12 (as Methylcobalamin) 3 mg
Betaine Anhydrous (Trimethylglycine) 1.8 g 

This is from the thorne research website.
I love the old one (helps with depression) but the plus gives me a migraine.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by C***Y on 11 September 2025*

Excellent product for MTHFR genetic disorder

### ⭐⭐⭐⭐⭐ Review
*by A***L on 4 August 2025*

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

### ⭐⭐⭐⭐⭐ Review
*by M***C on 2 February 2026*

Great product, contains Betaine?TMG too which is essential for proper maintenance of homocysteine levels.

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*Product available on Desertcart Kyrgyzstan*
*Store origin: KG*
*Last updated: 2026-02-21*